Download E-books Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects PDF

Eric Engel and Stylianos Antonarakis have written the main authoritative and very important reference on molecular and scientific facets of uniparental disomy (UPD) and genomic imprinting so far. Genomic Imprinting and Uniparental Disomy in drugs good points accomplished overviews of a large number of genetic issues associated with UPD, with a powerful emphasis on medical results. This publication will offer readers with the instruments essential to establish and deal with ailments linked to nontraditional chromosomal inheritance.

Genomic Imprinting and Uniparental Disomy in drugs gains convenient tables summarizing scientific phenotypes and chromosomal involvement in UPD, in addition to transparent illustrations on imprinting mechanisms and diagnostic checking out. This authoritative, thoroughly updated useful reference can be invaluable for any scientific geneticist, genetic counselor, general practitioner, or researcher encountering sufferers with such problems or learning advanced affliction mechanisms.

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Download E-books Treatment of Cystic Fibrosis and Other Rare Lung Diseases (Milestones in Drug Therapy) PDF

By Arata Azuma, Michael S. Schechter

This quantity describes the pathogenesis and pathophysiology of a number of pulmonary ailments in addition to their therapy. It additionally discusses the underlying genetic and molecular organic foundation, which opens the way in which for brand spanking new remedies for those conditions.

It makes a speciality of the therapy of cystic fibrosis together with CFTR (cystic fibrosis transmembrane-conductance regulator) modulator treatments, drug cures that increase airway floor liquid in addition to anti inflammatory and anti-infective cures. additional subject matters comprise long term, low-dose macrolide remedy for diffuse panbronchiolitis; novel brokers for formerly untreatable idiopathic pulmonary fibrosis; attainable new remedies for pulmonary alveolar proteinosis (PAP); and a number of novel healing objectives for treating lymphangiomyomatosis. examine into those stipulations has ended in significant advances in our knowing of the underlying genetic and molecular foundation of this disorder, and to dramatic advancements in survival and caliber of existence for affected individuals.

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Download E-books Don't Swallow Your Gum: And Other Medical Myths Debunked PDF

Men with enormous ft have enormous penises
You should still drink at the very least 8 glasses of water a day
Sugar makes little ones hyper
Eating at evening makes you fat
Chewing gum remains on your belly for seven years
You lose forty% of your physique warmth via your head

Every day, you pay attention or imagine issues approximately your physique and health and wellbeing which are simply no longer actual. possibly you observed them on television, learn them in magazines or heard them from acquaintances (or even a doctor). This ebook is for an individual who has puzzled concerning the fact at the back of those myths.

Funny, wacky and entire of attention-grabbing evidence, Don't Swallow Your Gum explains why such a lot of of these bizarre and worrisome issues we predict approximately bodies are mistaken.

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Download E-books Praxisbuch Herz-CT: Grundlagen - Durchführung - Befundung (German Edition) PDF

Praxisbuch Herz-CT. Sie haben sich gefragt, used to be sich hinter diesem Titel verbirgt? Eine kurze Antwort vorneweg sei erlaubt: Das Buch fasst auf sehr praxisrelevante Weise alles zusammen, used to be Sie für die Herzbildgebung mithilfe der Computertomographie in ihrem Alltag benötigen. Nach gründlichem Studium unzähliger Bücher haben wir beschlossen, dieses Buch zu v- fassen. Ein immer wiederkehrendes Gefühl sagte uns, dass es genau hier – nämlich bei der prax- nahen Vermittlung der Herz-CT – eine Lücke gibt, die wir gerne schließen wollen. Das Buch soll Ihnen, Ärztinnen und Ärzte wie auch MTRA, auf kurze, aber treffende paintings und Weise von den theoretischen Grundlagen über die Durchführung der Untersuchung bis zur Befundung und Interpretation der Bilder die Herz-CT vermitteln. Insbesondere ist es uns ein zentrales Anliegen, essenzielle Informationen rasch verfügbar zu machen. Hilfreich hierbei sind zahlreiche Illustrationen und Zeichnungen, viele übersichtliche Tabellen sowie Tipps und tips zu jedem einzelnen Thema. Besonders bemüht haben wir uns, die sonst oftmals schwierig zu verstehenden physikalischen Grundlagen der CT-Technik bei der Herzbildgebung prägnant und leicht verständlich zu beleuchten. Die Themen des Buches reichen von der Wahl des Untersuchungs- und Kontrastmitt- protokolls über die Datenrekonstruktion bis hin zur Bildinterpretation von normalen und - thologisch veränderten Herzkranzgefäßen, Herzkammern, Herzklappen sowie perikardialen Strukturen. Die übersichtliche Gliederung und die Aufteilung in mehrere kurze Kapitel erlauben es, sowohl relevante Fakten rasch zu erfassen als auch wichtige Informationen während der Untersuchung problemlos nachzuschlagen.

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Download E-books Neonatal Immunity (Contemporary Immunology) PDF

A serious overview of the vintage, as wells as so much recent-and particularly seminal-findings in regards to the phenotypic and molecular features of either fetal and neonatal B and T cells, the cells that mediate antibody and mobile immune responses in newborns and babies. Dr. Bona indicates how the antibody reaction of neonates is modulated by means of maternal antibodies and the way, every now and then, this may reason temporary or life-threatening neonatal autoimmune disorder. He additionally describes the features of neonatal tolerance caused via overseas allo- and self-antigens, that are the root for figuring out impaired boy or girl immune reaction and which supply a cause for the advance of effective neonatal vaccines. by way of making transparent the features and adjustments among the immune process and the immune responses of either newborns and babies, in comparison to these of adults, Dr. Bona deals insights and not easy hypotheses that promise to aid conquer the bad responses of neonates to varied antigens.

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Download E-books Immunity-Based Systems: A Design Perspective (Advanced Information Processing) PDF

By Yoshiteru Ishida

After I got here to grasp Jerne's community concept at the immune approach, I turned thinking about the immune approach as a data procedure. the most professional­ totypes for organic info platforms were the neural platforms and the mind. even though, the immune approach is not just an engaging informa­ tion process however it may supply a layout paradigm for synthetic info platforms. With this kind of attention, I initiated a venture titled "autonomous decentralized reputation mechanism of the immune community and its applica­ tion to allotted info processing" in 1990 below a Grant-in-Aid for clinical study on a concern region ("Autonomous dispensed Systems") supported by way of the Ministry of schooling, technological know-how, and tradition. throughout the venture, I promoted the concept the immune process can be a prototype of self sustaining allotted structures. After the venture, we prepared a world workshop on immunity­ dependent structures in 1996 along with the overseas convention on Multi-Agent platforms held in Kyoto, Japan. lately, there were a number of overseas meetings concerning themes encouraged by way of the immune process and more and more study papers concerning the subject. In scripting this publication, a decade after the venture, I nonetheless think that the immune process could be a prototype, a compact yet subtle process that nature has proven us for construction man made details structures during this community age of the twenty-first century.

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Download E-books Research on Nitrification and Related Processes, Part B: 496 (Methods in Enzymology) PDF

The international nitrogen cycle is the single such a lot impacted via mankind. The earlier decade has replaced our view on many points of the microbial biogeochemical cycles, together with the worldwide nitrogen cycle, that is regularly as a result of super advances in equipment, concepts and methods. Many novel approaches and the molecular stock and organisms that facilitate them were found purely in the final five to ten years, and the method is in development. This quantity presents cutting-edge updates on equipment and protocols facing the detection, isolation and characterization of macromolecules and their internet hosting organisms that facilitate nitrification and comparable methods within the nitrogen cycle in addition to the demanding situations of doing so in very various environments.

Provides cutting-edge replace on tools and protocols bargains with the detection, isolation and characterization of macromolecules and their web hosting organisms  bargains with the demanding situations of very different environments.

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Download E-books Gene Therapy Technologies, Applications and Regulations: From Laboratory to Clinic PDF

By Anthony Meager

Gene treatment applied sciences, purposes and laws From Laboratory to health facility Edited through Anthony Meager department of Immunobiology, The nationwide Institute for organic criteria and regulate, South Mimms, united kingdom the advance of gene-based applied sciences has been quick over the last decade and has accordingly ended in a surge of curiosity in human gene remedy, the planned move of genes to somatic cells to treatment or alleviate sickness indicators. countless numbers of scientific protocols related to variously designed vectors for effective gene move were constructed. even if, using such advanced 'gene medications' containing in all likelihood heritable genes has raised a variety of issues relating to caliber, efficacy and protection. Encompassing fresh advancements within the box and addressing present matters this book:
* surveys a number of the present applied sciences for getting ready vectors to be used in gene remedy protocols
* studies the applying of gene-mediated remedies to more than a few clinical conditions
* considers the regulatory facets of gene remedy together with product caliber and security requirements
* appraises the move of applied sciences from laboratory to health facility with reference to the attendant standards and amenities for:
* stable laboratory perform (GLP) stipulations within the R&D laboratory
* large-scale creation tools and reliable production perform (GMP)
* present in-process and ultimate product testing

Written via overseas specialists acquainted with many elements of human somatic gene treatment, this publication can be a vital advisor for these embarking on gene remedy applied sciences suitable to necessities of construction and checking out of goods (and approaches) required to satisfy latest laws, together with caliber, efficacy and security concerns.

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Download E-books Molecular Biology of Human Cancers PDF

By Wolfgang Arthur Schulz

During the last 3 a long time, wisdom at the molecular biology of human cancers has significantly increased. a number of genes and proteins fascinated by melanoma improvement and development were outlined and lots of mechanisms on the molecular, mobile or even tissue point were, at the least in part, elucidated. Insights have additionally been received into the molecular mechanisms underlying carcinogenesis via chemical, actual, and organic brokers and into inherited susceptibility to melanoma. consequently, half I of the booklet offers the various molecules and mechanisms more often than not vital in human cancers. Following an summary at the melanoma challenge, person chapters care for melanoma genetics and epigenetics, DNA harm and service, oncogenes, tumor suppressors, regulatory pathways in melanoma, apoptosis, mobile senescence, tumor invasion, and metastasis. A consensus is rising that whereas those universal mechanisms and molecules are all appropriate to human cancers, in every one melanoma variety (or even subtype) a variety of them are very important. For chosen cancers, the course from genetic and epigenetic adjustments to their organic and medical habit can already be traced. half II of the e-book offers a extensive, yet exemplary number of cancers that function paradigms to demonstrate this aspect. in reality, melanoma learn has now reached a severe degree, within which the amassed wisdom on molecular mechanisms is progressively translated into more desirable prevention, prognosis, and remedy. The nation, pitfalls, and capability of those efforts are summarized partially III. greater than ever, melanoma examine is now an interdisciplinary attempt which calls for a easy wisdom of commonplace phrases, evidence, matters, and ideas. the purpose of this publication is to supply complicated scholars and practitioners of other disciplines with this foundation, bridging the space among ordinary textbooks of molecular biology, pathology, and oncology at the one hand and the really good melanoma literature at the different.

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Download E-books microRNA: Medical Evidence: From Molecular Biology to Clinical Practice (Advances in Experimental Medicine and Biology) PDF

This quantity explores microRNA functionality in a big selection of human problems, supplying a medical foundation for precision drugs and customized treatments utilizing those molecules. The twenty-one chapters, all authored via internationally-renowned specialists, open with an advent contextualizing microRNA manipulation inside of today’s projects in the direction of precision medication. the subsequent chapters discover the medical position of microRNAs within the analysis and remedy of metabolic and cardiovascular problems, targeting mitochondrial health, arterial high blood pressure, cardiovascular home improvement, cerebrovascular ailment, pulmonary high blood pressure, diabetic kidney illness, and kidney transplantation. the next chapters talk about the significance of microRNAs within the wound therapeutic strategy and in pores and skin disorder, within the pathogenesis of allergic reaction, in human ovulation, and in an infection. The e-book concludes with chapters  which define the rising function of microRNAS in doping and aspect microRNA profiling.

microRNA: scientific Evidence is an incredible better half to both microRNA: simple Scienceand microRNA: Cancer. Taken jointly, those 3 books offer a cutting-edge review of this rapidly-expanding and engaging box, from the

molecular point to scientific

practice. it is going to be beneficial to scientific scholars, physicians, and researchers, as a whole and precise advisor within the exploration of microRNA in simple technology, melanoma and medical practice.

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